---

Nonalcoholic fatty liver disease (NAFLD) represents a global health problem affecting approximately 30% of the population, ranging from simple steatosis to more severe conditions such as nonalcoholic steatohepatitis (NASH) and cirrhosis. Recent research highlights a worrisome link between zinc deficiency and NAFLD, as zinc plays an important role in metabolic processes, including glucose and lipid metabolism, insulin signaling, and antioxidant defense.This review synthesizes the existing literature on the mechanisms related to zinc deficiency in NAFLD, emphasizing its contribution to endoplasmic reticulum stress, inflammation, insulin resistance, and oxidative stress. Evidence suggests that zinc supplementation may improve liver metabolic and histological parameters in NAFLD patients.Clinical trials show that zinc supplementation can lead to a significant reduction in body mass index, waist circumference, and liver enzymes. However, although these findings are promising, they require further investigation to determine optimal doses and long-term effects. Overall, addressing zinc deficiency can be a critical aspect of NAFLD management alongside traditional lifestyle modification.

---

Benign thyroid nodules are among the most common endocrine disorders, potentially causing compressive symptoms or cosmetic concerns. The two main therapeutic approaches for managing these nodules are thyroid surgery and radiofrequency ablation (RFA). While surgery is considered the standard method with high efficacy in nodule removal, it carries potential risks such as postoperative complications, prolonged hospitalization, and scarring. In contrast, RFA, as a minimally invasive technique, offers advantages including reduced risk of complications, preservation of normal thyroid function, shorter recovery time, and minimal scarring. Based on current evidence, RFA can be considered a safe and effective treatment option for patients with benign thyroid nodules.