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Comparison of platelet level, hemoglobin and platelet-to-hemoglobin ratio in patients with diabetic foot ulcers and diabetic patients without ulcers in Imam Khomeini Hospital in Ardabil city in 2022
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Bita Rahmani1    , Ahmad Ghasemi *2 |
1- azad ardabil & Department of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
2- azad ardabil & Department of Medicine, Ardabil Branch, Islamic Azad University, Ardabil, Iran. , ahmadghasemi720@gmail.com |
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Abstract: (155 Views) |
Background: Diabetes mellitus is one of the most common metabolic diseases worldwide, with an increasing annual prevalence and numerous complications. Among its most serious and life-threatening complications is diabetic foot ulcer (DFU), which substantially increases the risk of amputation and mortality. Previous studies have shown that hematological indices such as hemoglobin and platelet count may play a role in predicting this complication. The present study aimed to compare platelet, hemoglobin, and platelet-to-hemoglobin ratio (PHR) levels in diabetic patients with and without diabetic foot ulcers.
Methods: This case-control study was conducted on 200 diabetic patients with foot ulcers and 200 diabetic patients without ulcers who were hospitalized at Imam Khomeini Hospital, Ardabil. The two groups were matched for age and sex. Data analysis was performed using SPSS software version 21, and independent t-test and Mann–Whitney U test were applied to compare differences between the two groups. A p-value less than 0.05 was considered statistically significant.
Results: The mean hemoglobin level in the group without foot ulcers (13.6 ± 0.3) was significantly higher than in the group with foot ulcers (10.75 ± 0.29; p = 0.001). The mean platelet count in the group without foot ulcers (299,053.61 ± 102,684.21) was significantly lower than in the group with foot ulcers (353,675.64 ± 103,281.59; p = 0.001). Moreover, the mean PHR value was significantly lower in the group without foot ulcers (22,008.93 ± 7,570.17) compared to the group with foot ulcers (32,921.21 ± 9,663.53; p = 0.001).
Conclusion: The present study demonstrated that platelet, hemoglobin, and PHR indices could serve as potential predictive markers for diabetic foot ulceration. Regular assessment of these hematological parameters in diabetic patients is of great clinical importance. |
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| Keywords: Diabetic foot ulcer, Platelet count, PHR index |
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Full-Text [PDF 671 kb]
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Type of Study: Original |
Subject:
Special
Received: 2025/09/3 | Accepted: 2025/10/18 | Published: 2025/12/31
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Clinical trials code: نداریم
rahmani B, ghasemi A. (2025). Comparison of platelet level, hemoglobin and platelet-to-hemoglobin ratio in patients with diabetic foot ulcers and diabetic patients without ulcers in Imam Khomeini Hospital in Ardabil city in 2022. Health Res Develop. 3(4), 20-26.
URL: http://jhrd.trjums.ac.ir/article-1-127-en.html
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