fa تاثیر فعالیت ورزشی و مکمل‌یاری زعفران بر شاخص‌های التهابی و اکسیداتیو: مطالعه نظام‌مند و فراتحلیل تخصصي Special پژوهشي Original <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:yekanYW;"><span style="line-height:2;"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" times=""><span lang="FA"><span style="color:black"><span style="background-color:#ffffff;">سابقه و هدف:</span></span></span><span style="background-color:#ffffff;"> </span><span lang="AR-SA"><span style="background-color:#ffffff;">انجام فعالیت ورزشی، تولید گونه‌های واکنش‌پذیر اکسیژن و فاکتورهای التهابی را تحت تاثیر قرار می‌دهد که گیاهان دارویی نقش مهمی در کاهش این شاخص‌ها دارد. مکمل‌یاری زعفران به عنوان راهکار تغذیه‌ای برای تعدیل التهاب و استرس اکسیداتیو ناشی از فعالیت ورزشی مورد توجه محققان قرار گرفته است. بنابراین هدف از تحقیق حاضر بررسی تاثیر ترکیبی فعالیت ورزشی و مکمل‌یاری زعفران بر شاخص‌های التهابی و اکسیدانی بصورت مطالعه مروری نظام‌مند و فراتحلیل می‌باشد.</span></span><span lang="FA"><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" times=""><span lang="FA"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">مواد</span></span></span></span><span style="background-color:#ffffff;"> </span><span lang="FA"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">و</span></span></span></span><span style="background-color:#ffffff;"> </span><span lang="FA"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">روش‌ها</span></span></span></span><span lang="AR-SA"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">:</span></span></span></span><span style="background-color:#ffffff;"> </span></span></span></span><span dir="RTL" lang="AR-SA"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">جستجوی سیستماتیک مقالات منتشر شده به زبان انگلیسی و فارسی از پایگاه‌های اطلاعاتی اسکوپوس، ساینس دایرکت، پاب‌مد، وب آو ساینس، مرکز اطلاعات علمی جهاد دانشگاهی و مگیران تا 21 ژانویه سال 2026 انجام شد و وارد فراتحلیل شدند. </span><span style="background:lime"><span style="background-color:#ffffff;">اختلاف میانگین استاندارد شده (</span></span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">SMD</span></span></span></span></span><span dir="RTL" lang="AR-SA"><span style="background:lime"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">) </span></span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">و فاصله اطمینان 95% (</span></span></span></span></span><span style="background:lime"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">CI) </span></span></span></span><span dir="RTL" lang="AR-SA"><span style="background:lime"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">با استفاده از مدل</span></span></span></span></span><span style="background-color:#ffffff;"> </span><span dir="RTL" lang="FA"><span style="background:lime"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">تصادفی محاسبه شد.</span></span></span></span></span><span style="background-color:#ffffff;"> </span><span dir="RTL" lang="AR-SA"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">همچنین برای تعیین عدم تجانس (ناهمگونی) مطالعات از شاخص </span></span></span></span><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">I</span>^{<span style="background-color:#ffffff;">2</span>}<span style="background-color:#ffffff;"> استفاده گردید و سوگیری انتشار با تحلیل بصری فونل پلات و آزمون Egger مورد بررسی قرار گرفت.</span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" times=""><span lang="FA"><span style="color:black"><span style="background-color:#ffffff;">یافته</span><span style="letter-spacing:-.2pt"><span style="background-color:#ffffff;">‌</span></span><span style="background-color:#ffffff;">ها</span></span></span><span lang="AR-SA"><span style="color:black"><span style="background-color:#ffffff;">:</span></span></span><span style="background-color:#ffffff;">&nbsp;</span></span></span></span><span dir="RTL" lang="FA"><span b="" mitra=""><span style="background-color:#ffffff;">نتایج فراتحلیل حاضر نشان داد که</span></span></span><span dir="RTL" lang="FA"><span b="" nazanin=""><span style="background-color:#ffffff;"> انجام فعالیت ورزشی به همراه مصرف مکمل زعفران باعث کاهش معنی‌دار سطوح </span></span></span><span dir="RTL" lang="FA"><span b="" nazanin=""><span style="background-color:#ffffff;">فاکتور نکروزدهنده‌ی تومور-آلفا </span><span style="background:lime"><span style="background-color:#ffffff;">(</span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">30</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">/</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">2- تا 29/0- </span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">CI=</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">95</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">% </span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">، </span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">29/1-</span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">=</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">SMD</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">) </span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">می‌گردد. ولی با این وجود تغییر معنی‌داری در سطوح </span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">اینترلوکین-6 (</span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">91</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">/</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">0 تا 03/1- </span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">CI=</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">95</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">% </span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">، </span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">06/0-</span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">=</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">SMD</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">) </span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">و سطوح مالون‌دی‌آلدهید </span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">(</span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">31</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">/</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">0- تا 17/1- </span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">CI=</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">95</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">% </span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">، </span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">43/0-</span></span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">=</span></span></span></span><span style="background:lime"><span new="" roman="" times=""><span style="background-color:#ffffff;">SMD</span></span></span><span dir="RTL" lang="FA"><span style="background:lime"><span b="" nazanin=""><span style="background-color:#ffffff;">)</span></span></span></span><span style="background-color:#ffffff;"> </span><span dir="RTL" lang="FA"><span b="" nazanin=""><span style="background-color:#ffffff;">مشاهده نگردید.</span></span></span><br> <span dir="RTL" lang="FA"><span style="color:black"><span style="letter-spacing:-.1pt"><span style="background-color:#ffffff;">نتیجه گیری:</span></span></span></span><span lang="FA"><span style="color:black"><span style="background-color:#ffffff;"> مکمل‌یاری زعفران در کنار فعالیت ورزشی، استراتژی بسیار موثری برای سرکوب فاکتور نکروزدهنده تومور آلفا به عنوان شاخص اصلی التهاب سیستمیک می باشد و از افزایش سطوح مالون‌دی‌آلدهید جلوگیری می‌نماید</span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:yekanYW;"><span new="" roman="" times=""><span style="letter-spacing:-.2pt"><span style="background-color:#ffffff;">Background and purpose:</span></span><span style="background-color:#ffffff;"> Exercise affects the production of reactive oxygen species and inflammatory factors, and medicinal plants play an important role in reducing these indicators. Saffron supplementation has been considered by researchers as a nutritional solution for modulating inflammation and oxidative stress caused by exercise. Therefore, the purpose of this study was to investigate the combined effect of exercise and saffron supplementation on inflammatory and oxidant indices through a systematic review and meta-analysis.</span></span><br> <span new="" roman="" times=""><span style="background-color:#ffffff;">Materials and methods: A systematic search of articles published in English and Persian was conducted from the databases Scopus, Science Direct, PubMed, Web of Science, SID, and Magiran until January 2026 and entered into meta-analysis. </span><span style="background:lime"><span style="background-color:#ffffff;">The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using a random model</span></span><span style="background-color:#ffffff;">. The I</span>^{<span style="background-color:#ffffff;">2</span>}<span style="background-color:#ffffff;"> index was also used to determine the heterogeneity of studies, and publication bias was examined using funnel plot analysis and Egger&#39;s test.</span></span><br> <span new="" roman="" times=""><span style="background-color:#ffffff;">Results: The results of the present meta-analysis showed that exercise training combined with saffron supplementation significantly reduced tumor necrosis factor-alpha levels (</span><span style="background:lime"><span style="background-color:#ffffff;">SMD = -1.29, 95% CI =-2.30 to -0.29). However, no significant changes were observed in interleukin-6 levels (SMD = -0.06, 95% CI =-0.91 to -1.03) and malondialdehyde levels (SMD = -0.43, 95% CI =-0.31 to -1.17).</span></span></span><br> <span new="" roman="" times=""><span style="background-color:#ffffff;">Conclusion: Saffron supplementation, along with exercise training, is a very effective strategy for suppressing tumor necrosis factor alpha, a key indicator of systemic inflammation, and prevents the increase in malondialdehyde levels.</span></span></span></span></div> فعالیت ورزشی, زعفران, مالون‌دی‌آلدهید, اینترلوکین-6, فاکتور نکروزدهنده‌ی تومور-آلفا Exercise Training, Saffron, Malondialdehyde, Interleukin-6, Tumor Necrosis Factor Alpha, 0 0 http://jhrd.trjums.ac.ir/browse.php?a_code=A-10-165-2&slc_lang=fa&sid=1 yazgaldi nazari یازگلدی نظری y.nazari53@gmail.com 2032310171 0009-0003-1563-0611 Yes golestan university دانشگاه گلستان araz nazari عراز نظری araznazari@gmail.com 2030871461 0009-0001-2271-937X No saravan university دانشگاه سراوان